Oral acne medicine is commonly used to confront serious cases of anti-inflammatory acne resulting from overactive sebaceous glands. This is usually some sort of oral antibiotic such as Minocycline acne medicine or Accutane. This medicine should not be taken during pregnancy because of its connection with birth defects. Some minor side effect cause by Accutane are chapped lips and depression. Combination acne products containing benzoyl peroxide and the topical antibiotics have been shown to both: prevent the development of antibiotic resistance in acne patients; and confer significant clinical improvement to patients who have already developed antibiotic resistance.

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